A PLEA TO PROVIDE BEST EVIDENCE IN TRIALS UNDER SAMPLE-SIZE RESTRICTIONS: THE EXAMPLE OF PIOGLITAZONE TO RESOLVE LEUKOPLAKIA AND ERYTHROPLAKIA IN FANCONI ANEMIA PATIENTS

Abstract In planning a clinical trial for demonstrating the efficacy of pioglitazone to resolve leukoplakia and erythroplakia in Fanconi anemia patients we had to discuss the need for a randomized controlled trial particularly under sample-size restrictions as very promising results were available from a single-arm clinical trial.Unfortunately, at

Abstract Background People who inject drugs (PWID) in Europe are at an increased risk of HIV/AIDS, chronic viral hepatitis B (HBV) and C (HCV), and tuberculosis (TB).We aimed to complement the evidence base on interventions optimising their care cascade with evidence from models of good practice (MoGPs) implemented in the EU/EEA and countries from

In adult life, many of the social determinants of health are connected to working life.Yet, our knowledge of the role of work-related factors for the risk of stroke is fairly limited.In contemporary occupational health research, the Demand-Control Model (DCM) is frequently used to measure work stress.Previous literature reviews of the association o